A nine-year-old slave built the galaxy's golden conscience. Decades later he became its most feared killer. The rhyme between them is the moral architecture of the entire saga.
The joke lands before the theme does. When The Phantom Menace reveals that C-3PO, the fussiest and most quietly beloved protocol droid in the galaxy, was built from scavenged parts by a nine-year-old slave on a backwater desert world, the first reaction is a laugh. The most famous worrier in cinema, the golden conscience forever predicting the odds of survival, was a child's passion project.
And in that single retroactive stroke, every utterance of "Thank the Maker!" across the original trilogy turns inside out. The Maker is not some abstract divinity of the assembly line. The Maker is Anakin Skywalker. The Maker is Darth Vader, the most feared figure in the galaxy, a villain whose every clipped line became scripture. C-3PO spends three films thanking, with prim and total sincerity, the man who will become that killer, and he never once knows it. 
It is a genuinely funny piece of engineering, and on that basis alone it earns its place. But the gag is a doorway, not a destination. What it opens onto is a thematic rhyme George Lucas had been circling for years. As he put it in 1997, after he had already finished writing The Phantom Menace:
"Having machines, like the droids, that are reasonably compassionate and a man like Vader who becomes a machine and loses his compassion was a theme that interested me."
Read that twice.
The droids keep their compassion. The man loses his.
The whole moral architecture of the saga is hiding in that sentence, and C-3PO is the load-bearing beam.
A Man-Like Machine, a Machine-Like Man
He is a man-like machine. Vader is a machine-like man. They are the same idea pointed in opposite directions.
Because C-3PO is Vader's inverse, exactly and deliberately. One is built from circuitry and learns to feel; the other is born feeling and is rebuilt, piece by piece, until almost nothing of the feeling survives. Once you see it you cannot unsee it. Their arcs form a perfect crossing, a chiasmus drawn across the entire saga, and they pass each other somewhere over a lava field on Mustafar.
Watch the trajectories. C-3PO begins as exposed wiring and bare servos, a half-finished thing apologizing for his own incompleteness. He gains his golden plating, then his polish, then a personality so vivid it overwhelms the metal it lives in: anxiety, loyalty, snobbery, devotion, a bottomless capacity for fear on behalf of people he loves. By Return of the Jedi he is more emotionally legible than half the humans around him. Anakin runs the film backwards. He starts as the most gifted and openhearted boy in the galaxy and is stripped down by degrees, a hand first, then the rest of his limbs, then his lungs, his voice, his face, until what remains is a suit with a respirator where a man used to breathe. The compassion is amputated alongside the flesh. By the time the helmet seals shut, the droid has more soul in him than the Sith Lord.
Two Makers, Two First Steps
The two creation scenes mirror each other on purpose, though one plays as comedy and the other as horror. Anakin activates C-3PO and watches his little machine take its first wobbling steps, and his maker looks on with the uncomplicated pride of a child who has made something good. Years later, on Palpatine's operating table, the freshly assembled Darth Vader rises for the first time, and his maker looks on too. The pride is there in both scenes. The difference is everything. Anakin built C-3PO to be a friend, a helper, a companion for his mother in a house with not enough hands. The Emperor built Vader to be a tool, an instrument, a weapon that breathes. One creation was an act of love and the other an act of use, and the things they made carry that intention in their wiring for the rest of their existence. C-3PO is forever reaching toward the people around him. Vader is forever an extension of someone else's will.
There is even a visual seam where the two halves of the idea touch. The first version of Anakin's mechanical hand, revealed when the leather glove comes away, has a clear kinship with the warm gold C-3PO will wear in every film to come. The shapes echo. But the meaning is reversed once more. On Anakin, the metal hand is the first concession, the opening wound, the place where the machine begins to colonize the man. He has lost something, and we can name the day he started losing it. Yet he is still, in that moment, far more man than machine. The hand is a single dark note. The symphony of loss has not begun. C-3PO, meanwhile, will wear nearly identical gold across his entire body and grow only more human inside it. Same material, opposite verdict.
The Geometry of Compassion
This is the hinge the whole saga turns on, and it is worth saying plainly: in Lucas's universe, the line between man and machine was never about flesh. It was about feeling. The droids are not lesser beings who happen to be made of metal. They are, in the only way that finally counts, persons, because they care, they fear, they stay loyal at cost to themselves, they grieve. Vader's horror is not that he is part machine. Luke is part machine by the end of The Empire Strikes Back, his own severed hand replaced with a prosthetic that rhymes with his father's, and Luke stays human throughout. Vader's horror is that he chose, again and again, to stop caring, and the suit is only the outward form of an inward surrender. The mask is a confession.
Which is why the ending works the way it does. When Vader finally throws his master into the abyss, he is not winning a fight. He is recovering a feeling, and his road to redemption completes only in the act of dying. The film insists on showing us the consequence: he asks Luke to remove the helmet so he can look at his son with his own eyes, just once, before he goes. The machine peels back and a man is underneath, scarred and dying but unmistakably human, because in his last hour he found his compassion again. He becomes a man at the precise moment he becomes mortal. The arc completes. The machine-like man dies a man.
And C-3PO never knows any of it.
His memory is wiped at the end of Revenge of the Sith, so the droid built by a loving boy goes on through the galaxy with no idea that his Maker became the thing the galaxy fears. He fusses and frets and thanks his Maker, sincerely, in the presence of the very man who made him, and the man does not recognize his own creation, and the creation does not recognize its own creator.
The one who kept his compassion has forgotten.
The one who lost his has remembered too late. They stand in the same rooms, on the same battle stations, and the rhyme hums underneath them, unspoken and complete: the man who became a machine, and the machine who became, in every way that matters, a man.